António Marinho, MD, PhD

Integrated PhD Researcher

orcid.org/0000-0002-3295-6723

Academic degrees:

PhD in Medical Sciences

Medical Doctor

Current Positions:

• Assistente Hospitalar Graduado, CHP-HSA

Research interests:

• Effects of vitamin D in immune system, namely on regulatory T cells

• Vitamin D role in autoimmune disease development

• Vitamin D as new therapeutic target for autoimmune disease

Research area keywords:

Autoimmunity, Immune regulation, Systemic Lupus Erythematosus, Vitamin D

Major Scientific Achievements:

• Demonstration that vitamin D supplementation is a suitable therapeutic approach for SLE with an impact in immune system

• Demonstration that susceptibility for SLE has a strong genetic component for wich HLA locus and polymorphisms in Vitamin D signaling pathway have an important contribution

• Integration in the research group that observed that half of the northen Portuguese is vitamin D deficient.

Selected publications:

1. Andreia Bettencourt, Daniela Boleixa, Júlia Reis, José Carlos Oliveira, Denisa Mendonça, Paulo Pinho Costa, Berta Martins da Silva, António Marinho, Ana Martins da Silva. Serum 25-hydroxyvitamin D levels in a healthy population from the North of Portugal. J Steroid Biochem Mol Biol. 2018 Jan;175:97-101. doi: 10.1016/j.jsbmb.2016.11.005. Epub 2016 Nov 5.

2. António Marinho, Cláudia Carvalho, Daniela Boleixa, Andreia Bettencourt, Bárbara Leal, Judite Guimarães, Esmeralda Neves, José Carlos Oliveira, Isabel Almeida, Fátima Farinha, Paulo P. Costa, Carlos Vasconcelos, Berta M. Silva. Vitamin D supplementation effects on FoxP3 expression in T cells and FoxP3+/IL-17A ratio and clinical course in systemic lupus erythematosus patients: a study in a Portuguese cohort. Immunol Res. 2017 Feb;65(1):197-206. doi: 10.1007/s12026-016-8829-3

3. Carvalho C, Marinho A*, Leal B, Bettencourt A, Boleixa D, Almeida I, Farinha F, Costa PP, Vasconcelos C, Silva BM. Association between vitamin D receptor (VDR) gene polymorphisms and systemic lupus erythematosus in Portuguese patients.Lupus. 2015 Jul;24(8):846-53.

4. Bettencourt A, Carvalho C, Leal B, Brás S, Lopes D, Martins da Silva A, Santos E, Torres T, Almeida I, Farinha F, Barbosa P, Marinho A, Selores M, Correia J, Vasconcelos C, Costa PP, da Silva BM. The Protective Role of HLA-DRB1(∗)13 in Autoimmune Diseases. J Immunol Res. 2015; 2015:948723.

5. Tamirou F, Lauwerys BR, Dall'Era M, Mackay M, Rovin B, Cervera R, Houssiau FA; MAINTAIN Nephritis Trial Investigators. A proteinuria cut-off level of 0.7 g/day after 12 months of treatment best predicts long-term renal outcome in lupus nephritis: data from the MAINTAIN Nephritis Trial. Lupus Sci Med. 2015 Nov 12;2(1):e000123. doi: 10.1136/lupus-2015-000123. eCollection 2015

MSc thesis supervision (concluded):

• João Manuel Reis Caseiro Alves Pereira, Mestrado Integrado em Medicina, Importância do gene HLA-DRB1 nos pacientes com artrite reumatóide do norte de Portugal: estudo genético, radiológico e serológico - Artigo de Investigação. 2011.

• Ana Rita dos Santos Pacheco, Mestrado Integrado em Medicina, Células TH17 e Interleucina 17 em doentes com artrite reumatóide: um novo alvo terapêutico? - Artigo de revisão bibliográfica. 2011.

• Ana Isabel Parente Abreu Nunes, Mestrado integrado em Medicina, Factores de mau prognóstico na Artrite Psoriática - Artigo de revisão bibliográfica. 2011.

• Ana Sofia Lázaro Mendes, Mestrado integrado em Medicina Factores predisponentes ao desenvolvimento de Lúpus Eritematoso Sistémico e sua importância na prática clínica - Artigo de revisão bibliográfica. 2010.

• Pedro Valente, Mestrado integrado em Medicina, New insights in B cell depletion in autoimmune diseases - Artigo de revisão bibliográfica. 2009.