Anabela Rodrigues, MD, PhD

Principal Investigator

orcid.org/0000-0001-8818-2141

Academic degrees:

Habilitation, Instituto Ciências Biomédicas Abel Salazar (ICBAS), University of Porto(UP)

PhD, Instituto Ciências Biomédicas Abel Salazar (ICBAS), University of Porto(UP)

Medical Doctor , Faculdade Medicina Porto, University of Porto(UP)

Current Positions:

• Consultant nephrologist at the Department of Nephrology, Centro Hospitalar Universitario do Porto (CHUP), Portugal
• Head of the Peritoneal Dialysis Unit, since 1998 (CHUP)
• Associated Professor with Aggregation at ICBAS/UP
• Specialization in Management and Direction of Health Services. Porto Business School, University of Porto (UP)
• Principal Investigator of Nephrology, Dialysis and Transplantation Group of UMIB – I&D Unidade Multidisciplinar de Investigação em Biomedicina, ICBAS/UP
• President of the Group For Studies in Peritoneal Dialyis, from Portuguese Nephrology Society.
• Course Director in ICBAS/UP: Nephrology I and Nephrology II, Continuing Education Courses with Acreditation, ICBAS, Porto University
• Professor of Curricular Units in Integrated Master's Degree Medicine (MIM), ICBAS/UP; Masters of Clinical Nutrition, School of Nutrition and Food Sciences / UP
• Director of Post -Graduation Course with Accreditation from UEMS (Update Course Peritoneal Dialysis), 10 th Edition in 2017, Portuguese Society of Nephrology
• Member of Group of Epidemiology and Prevention of Chronic Renal Disease - CNAD advisory board, Portuguese Society of Nephrology and Health Ministry
• Coordination of Group of Studies of Peritoneal Dialysis, Portuguese Society of Nephrology
• Member of Scientific Committee of the Portuguese Society of Nephrology
• Advisor of Nephrology Interns, Curricular Internship of Peritoneal Dialysis in the Nephrology Unit, CHP, Hospital Santo Antonio, Porto

Research interests:

• Medicine, nephrology, renal transplantation, peritoneal dialysis
• Peritoneal transport, inflammation,
• Metabolic complications of PD,
• Statistical models in the evaluation of chronic dialysis programs and quality control
• Epidemiology of CKD

Research area keywords:

Peritoneal dialysis, Ultrafiltration failure, Survival, Obesity, Phosphate, Insulinresistance, Renal pancreatic transplantation

Selected publications:

1. Bernardo AP, Oliveira JC, Santos O, Carvalho MJ, Cabrita A, Rodrigues A. Insulin Resistance in Nondiabetic Peritoneal Dialysis Patients: Associations with Body Composition, Peritoneal Transport, and Peritoneal Glucose Absorption. Clin J Am Soc Nephrol. 2015 Oct 27. pii: CJN.03170315. [Epub ahead of print] PMID: 26507143
2. Martins LS, Malheiro J, Pedroso S, Almeida M, Dias L, Henriques AC, Silva D, Davide J, Cabrita A, Noronha IL, Rodrigues A. Pancreas-Kidney transplantation: Impact of dialysis modality on the outcome. Transpl Int. 2015 Aug;28(8):972-9. doi: 10.1111/tri.12565. Epub 2015 Apr 8. PMID: 25790131
3. Cotovio P, Rocha A, Carvalho MJ, Teixeira L, Mendonça D, Cabrita A, Rodrigues A. Better outcomes of peritoneal dialysis in diabetic patients in spite of risk of loss of autonomy for home dialysis. Perit Dial Int. 2014 Nov-Dec;34(7):775-80. doi: 10.3747/pdi.2012.00111. Epub 2014 Jan 2. PMID:24385330
4. Martins M, Rodrigues A, Pedrosa JM, Carvalho MJ, Cabrita A, Oliveira R. Update on the challenging role of biofilms in peritoneal dialysis. Biofouling. 2013 Sep;29(8):1015-27. doi: 10.1080/08927014.2013.824566. Review. PMID: 23998251
5. Teixeira L, Rodrigues A, Carvalho MJ, Cabrita A, Mendonça D. Modelling competing risks in nephrology research: an example in peritoneal dialysis. BMC Nephrol. 2013 May 24; 14:110. doi: 10.1186/1471-2369-14-110. PMID: 23705871

Ongoing projects:

Peritoneal histomorphology, biomarkers and clinical evolution in patients with chronic renal disease under peritoneal dialysis. PhD academic project. Nova Medical School NMS|FCM) PI Patrícia Quadros Branco . Advisor: A Rodrigues

Characterization and clinical impact of peritoneal protein losses in patients on peritoneal dialysis. . PhD academic project. Faculty of Medicine of the University of Porto Doctoral Program in Metabolism - Clinic and Experimentation. PI Maria Clara Costa Bonifácio Selores Santos. Advisor : A Rodrigues

MTM2014-52975-C2-1-R). Entity Promotora / Financiadora: Ministry of Economy and Competitiveness Spain. Multicenter project in Biostatistics and Medicine: "Inference in Structured Additive Regression (STAR) Models with Extensions to Multivariate Responses. Applications in Biomedicine "( Partnership: Unit of Biostatistics, Department of Statistics and Operations Research, School of Medicine, University of Santiago de Compostela, Spain.. Researcher Responsible at HGSA: A Rodrigues

Clinical Relevance of Polyomavirus BK Genotyping in Renal Transplantation. PhD Academic project in Medical Sciences Institution University of Porto - Biomedical Sciences Institute of Abel Salazar PI: Ana Paula Fontes da Rocha e Castro Advisor: A Rodrigues.

FCT-MEC-Portugal (SFRH / BD / 109201/2015) Peptidome And Proteome Peritoneal Dialysate Evolutionary Atlas (P3DEVOATLAS) - Granted by FCT PhD in Biomedical Sciences Institution : Universidade Nova De Lisboa - Faculty of Medical Sciences PI : Eduardo Araújo Co-advisor: A Rodrigues

Concluded projects:

Double Kidney and Pancreas Transplantation: Clinical and Metabolic Evolution and the Meaning of Pancreatic Anti-Islet Autoimmunity Expression. PhD Academic project. ICBAS /UP. PI Maria La Salete Soares Martins da Silva . Advisor: A Rodrigues

Metabolic Changes in Peritoneal Dialysis: Systemic and Functional Expression of the Peritoneal Membrane PhD Academic project . ICBAS/UP.PI: Ana Paula Bernardo Advisor: A Rodrigues

Statistical Models in the Evaluation of Chronic Dialysis Programs. PhD project in Applied Mathematics Faculty Sciences of the University of Porto and ICBAS; PI: Laetitia Teixeira Advisor : A Rodrigues.

Insights Into Peritoneal Dialysis Catheter Staphylococcal Biofilms: Characterization and Host-Pathogen Interactions. Individual postdoctoral fellowship SFRH / BPD / 73663/2010 Contemplated by FCT: Margarida Isabel de Barros Coelho Martins. Institution: CHP and ICBAS, in partnership with University of Minho, School of Health Sciences, Institute of Research in Life Sciences and Health and Department of Biological Engineering, University of Minho. Co-advisor : A Rodrigues

Prizes, honors, awards:

2015- Prize Raul Martins; Portuguese Society Of Nephrology. Award-winning article: Adipokines in peritoneal dialysis: relevant clinical impact according to body composition.

2014- Raul Martins Prize; Portuguese Society Of Nephrology. Award-winning article: Temporal trends in peritonitis rates, microbiology and outcomes: the major clinical complication of peritoneal dialysis.

2013- Raul Martins Prize; Portuguese Society Of Nephrology. Awardee article: Better outcomes of peritoneal dialysis in diabetic patients in spite of risk of autonomy for home dialysis.

2012- Nomination For The "Stanley Shaldon Prize" Highest Scoring Communication ERA EDTA Time-Dependent Covariates: A Problematic in Survival Analysis Taking Competing Risks into Account. An Example in Peritoneal Dialysis.

2012- Raul Martins Prize; Portuguese Society Of Nephrology. Award-winning article: Two-in-one protocol: simultaneous small-pore and ultrasmall-pore peritoneal transport quantification.

2012- ERA-EDTA Grants For Young Investigators. Assigned by the Communications Selection Committee of the 49th European Dialysis and Transplantation Congress, Paris, May 2012. Refuting a Taboo: Overhydration Prevalence Does Not Increase in Peritoneal Dialysis Patients - A Prospective Longitudinal Study.

2011- Raul Martins Prize; Portuguese Society Of Nephrology. Award-winning article Peritoneal membrane phosphate transport status: A cornerstone in phosphate handling inperitoneal dialysis.

2011- ERA-EDTA Grants For Young Investigators. Attributed by the Communications Selection Committee of the XLVIII Congress of the European Dialysis and Transplantation Association, Prague, Czech Republic. Are Competing Risks Important in Survival Analysis? An Example in Peritoneal Dialysis

2011- ERA-EDTA Grants For Young Investigators. Attributed by the Communications Selection Committee of the XLVIII Congress of the European Dialysis and Transplantation Association, Prague, Czech Republic. Clinical Outcomes of Diabetic Patients on Peritoneal Dialysis

2011- Best Oral Communication; 4th National Meeting of the Portuguese Contraception. Sexuality and Sexual Dysfunction in Women in Peritoneal Dialysis

2011- Nomination For The "Stanley Shaldon Prize" Title Of Work: Highest Scoring Abstracts Of The 2011 ERA-EDTA CONGRESS. Are Competing Risks Important In Survival Analysis? An Example In Peritoneal Dialysis Oral Communication

2011- 1st Free Communications Award-Best Communication Prize; VII National Congress of Ambulatory Surgery - I Iberian Congress of Ambulatory Surgery. Positive Impact of the Moncrief-Popovich Technique on Survival of the Peritoneal Dialysis Catheter

2010- ERA-EDTA Grants For Young Investigators. XLVII European Renal Association - European Dialysis and Transplantation - Best Abstracts presented by Young Authors Multifrequency Bioimpedance Assessment of Hydration Status in Peritoneal Dialysis and Factors Associated with Fluid Overload.

2010- Best Premium Presentation Award In The Peritoneal Dialysis Area; XXV Congress of the Portuguese Society of Nephrology - Renal Meeting 2010 Clinical Results of the Peritoneal Dialysis Mode in Diabetic Patients

2010- Raul Martins Prize; Portuguese Society Of Nephrology. Award winning article: Overweight rather than malnutrition is widely prevalent in peritoneal dialysis patients.

2009- Raul Martins Prize; Portuguese Society Of Nephrology. Award-winning article: Peritoneal membrane evaluation in routine clinical practice.

2008- Raul Martins Prize; Portuguese Society Of Nephrology. Award-winning article: Evaluation of peritoneal transport and membrane status in peritoneal dialysis: focus on incident fast transporters.

2007- Raul Martins Prize; Portuguese Society Of Nephrology. "Peritoneal fast transport in peritoneal dialysis patients is consistently associated with systemic inflammation.

2007- Prize For The Best Editorial / Review Article. Peritoneal Transport: The Problem of Fast Transport Status. He was honored with the Award for Best Editorial / Review Article Journal of Nephrology and Hypertension

2006- Best Presentations; XX Congress Of The Portuguese Society Of Nephrology. Automatic Peritoneal Dialysis - Experience From A Center

2005- Roche Prize; Portuguese Society Of Nephrology. Award-winning article: Massive Cell Mass as a Source of Intraperitoneal: a Determinant of Peritoneal Fast Transport in the Beginning of PD.

2005- Baxter Award; Portuguese Society Of Nephrology. Best Presentations to Congress 2005 Awards Longitudinal Transport and Environmental Monitoring

International collaborations:

• University Hospital La Paz. IdiPAZ. Madrid (Spain), University Hospital La Princesa. IP. Madrid (Spain) Hospital Santo Antonio. Porto (Portugal) University Hospital of Puerto Real. Cadiz (Spain) Hospital Santa Cruz. Lisbon (Portugal) Autonomous University of Madrid. Madrid (Spain) CBM Severo Ochoa. Madrid (Spain) Group of Peritoneal Studies of Madrid. REDinREN (RETICS. F.E.D.E.R. Funds) Fibroteam (Madrid Network on fibrosis studies) IRSIN. FRIAT. Characterization of miRNAs specifically and Differently Regulated ("Fibromirs") in Peritoneal Biopsies Associated with the Peritoneal Vessel Status Hyalinizing Vasculopathy. Project submitted to the International Society of Peritoneal Dialysis Society. Lead researcher Prof. R. Selgas. Researcher Responsible at HGSA: Anabela Rodrigues . Not granted
• H2020-PHC-2014-two-stage "Multicentre European study proposed by Jose M. Lopez-Novoa, University of Salamanca, Salamanca Biomedical Research Institute (IBSAL). Researcher Responsible at HGSA: Anabela Rodrigues. New Telematics Platform for Early and Remote Detection of Peritoneal Infections in Patients on Renal Replacement Therapy through Peritoneal Dialysis at home (PEARL). Not granted
• ERA-EDTA fellowship with Academic Medical Center, University of Amsterdam, and Erasmus Medical Center (EMC) Erasmus University Rotterdam. Principal Investigator Prof. R Krediet. Application to 2014 ERA-EDTA Research Program Call (BIOMARKERS OF CKD)
• Researcher Responsible at HGSA: Anabela Rodrigues. Biomarkers for peritoneal integrity.. Not granted.
• Multicenter project in Biostatistics Applications in Biomedicine "(MTM2014-52975-C2-1-R). Entity Promotora / Financiadora: Ministry of Economy and Competitiveness Spain. Partnership: Unit of Biostatistics, Department of Statistics and Operations Research, School of Medicine, University of Santiago de Compostela, Spain . Medicine Researcher Responsible at HGSA: Anabela Rodrigues. "Inference in Structured Additive Regression (STAR) Models with Extensions to Multivariate Responses.Status: Initiated.
• Funding Entity / Financier: Fresenius Medical Care. International and Multicentric Projec International Researcher in charge: Cláudio Ronco. Researcher Responsible at HGSA: Anabela Rodrigues.Project: Initiative for Patient Outcomes in Dialysis - Peritoneal Dialysis (PD) (IPOD-PD Study). Status Completed 2016
• Baxter Healthcare Corporation . Multicentre International. Rehearsal Coordinator: Joanne Bargman . Researcher Responsible at HGSA: Anabela Rodrigues.Starting Date: 2007. Clinical Trial: Impendia Trial - Multi Center Prospective, Randomized Trial to Demonstrate Improved Metabolic Control of PPEN vs. DDDD In Diabetic Capd Patients. Status: Completed - Suspended Recruitment.
• Baxter Healthcare Corporation and International Society of Peritoneal Dialysis European International and Multicentric Project. Principal Investigator at HGSA: Anabela Rodrigues Automated Peritoneal Dialysis Outcome Study (EAPOS). Status: Completed 2006.

PhD thesis supervision (concluded):

• Maria La Salete Soares Martins da Silva, MD. PhD Academic project in Medical Sciences Double Kidney and Pancreas Transplantation: Clinical and Metabolic Evolution and the Meaning of Pancreatic Anti-Islet Autoimmunity Expression. 2016
• Ana Paula Bernardo, MD, PhD Academic project . ICBAS/UP Metabolic Changes in Peritoneal Dialysis: Systemic and Functional Expression of the Peritoneal Membrane . 2016
• Laetitia Teixeira PhD project in Applied Mathematics Faculty Sciences of the University of Porto and ICBAS. Statistical Models in the Evaluation of Chronic Dialysis Programs.2015
• Insights Into Peritoneal Dialysis Catheter Staphylococcal Biofilms: Characterization and Host-Pathogen Interactions. Individual postdoctoral fellowship SFRH / BPD / 73663/2010 Contemplated by FCT: Margarida Isabel de Barros Coelho Martins. Institution: CHP and ICBAS, in partnership with University of Minho, School of Health Sciences, Institute of Research in Life Sciences and Health and Department of Biological Engineering, University of Minho. Co-advisor : A Rodrigues 2015

Science and Society:

Portuguese Society of Nephrology; Position: Scientific Committee

Portuguese Society of Nephrology (SPN); Position: Consultant to the Registry Office - Implementation of Individual Registry of Peritoneal Dialysis

European Society of Dialysis and Transplantation (ERA EDTA): Position: Congress Scientific Paper Selection Committee

International Society of Peritoneal Dialysis (ISPD): Position: Council Member

International Society of Peritoneal Dialysis: Position: Membership Committee - European Member

Peritoneal Dialysis Meeting EUROPD: Position: Congress Scientific Paper Selection Committee

ISPD Congress 2014 Position: Vice President

Knowledge dissemination and social intervention was promoted with several media

NDT Educational website select the certified presentation ERA EDTA / CME slide course

http://www.ndt-educational.org/page-22-138-0-351--cmeslidesforumarchive.php

Communication of scientific forum

http://trabajos.cin2011.uninet.edu/355/anabelarodrigues.pdf

Shared scientific profile

http://www.europd.com/page/speakers/speaker/42/-A-Rodrigues

Published book

Peritoneal Dialysis - A Dialysis Made At Home: For When Is The Option? Lidel Edition: 2010isbn: 978-972-757-723-1 http://www.lidel.pt/en/catalogo/ciencias-da-saude/nefrologia/dialise-peritoneal/

Several contents related to clinical and scientific activity were published in social media

Interview Neframea 2015 World Kidney Day, Apir

Year Xxxiii • Nº 172 Quarterly Publication • January / February / March 2015

Http://Www.Apir.Org.Pt/Up/Ficheiros-Bin2_Ficheiro_Pt_0653005001430255684-283.Pdf

Portal da Dialise 2015

http://www.portalialialise.com/Portal/Breves/Tag/Dialise-Peritoneal-3

SPNews2011; Portuguese Society of Nephrology - Anabela Rodrigues.

Dossier de Saúde DN Special World Kidney Day 2011 - Anabela Rodrigues

Jornal do Encontro Renal 2011 - Anabela Rodrigues.

Peritoneal dialysis

Preventive Review // Health And Medicine

http://lifestyle.sapo.pt/saude/saude-e-medicina/artigos/dialise-peritoneal

Medical Week - Interview. Anabela Rodrigues.

Video: Interview, EuroPD 2011. Anabela Rodrigues

https://www.youtube.com/watch?v=22VH2zJLYYo

World Kidney Day News Supplement

LifeSaudavel_12 Mar.Qxp 05-03-2009 Anabela Rodrigues

http://www.baxter.pt/sobre_baxter/SuplementoNVidaSaudavel_12Marco.pdf

Anabela Rodrigues Article: Peritoneal dialysis. Journal: Jasfarma Publication of the 20th Portuguese Congress of Nephrology. 2006.

Anabela Rodrigues. "Press Release" The Unit of Dialysis Peritoneal At HGSA -SPnews 2006 http://www.spnefro.pt/spnnews

A video was made as iconography for clinical session and dissemination with patients

Carlos Matos, Olívia Santos, António Marques, Anabela Rodrigues. Video on Peritoneal Dialysis for use in the Education on Chronic Renal Replacement Techniques Year: 2006