Idalina Beirão, MD, PhD

Integrated PhD Researcher

orcid.org/0000-0003-3903-0170

Academic degrees:

PhD

Current Positions:

• Director of the Pre-Graduate Medical Teaching Department of Centro Hospitalar do Porto, Porto
• Invited Full Professor, responsible for Semiology teaching in the course of Medicine of Institute of Biomedical Sciences Abel Salazar, University of Porto
• Nephrology Consultant at Department of Nephrology and Kidney Transplantation
• Coordinator of the Medical Education Office of Institute of Biomedical Sciences Abel Salazar, University of Porto
• Clinical Manager of the Outpatient Clinic of Nephrology at Centro Hospitalar do Porto, Porto

Research interests:

• Current research areas of interests are related with kidney disease, dialysis and kidney transplantation: Biomarkers of graft dysfunction and predictors of patient and graft outcomes, survival analysis and prognostic models; Biomarkers of chronic Kidney disease and the associated cardiovascular risk; Hereditary nephropathies, namely identification and characterization of Fabry patients in early stages of chronic kidney disease in Portugal. Also interested in research in medical education and in Transthyretin familial amyloid polyneuropathy (TTR-FAP) Val30Met.

Research area keywords:

Kidney transplantation, Dialysis and Kidney Disease, Hereditary nephropathies, Transthyretin familial amyloid polyneuropathy (TTR-FAP) Val30Met, Medical Education

Selected publications:

1. Beirão I, Cabrita A, Torres M, Silva F, Aguiar P, Laranjeira F, Gomes AM.Biomarkers and Imaging Findings of Anderson-Fabry Disease-What We Know Now.Diseases. 2017 Jun 11;5(2). pii: E15. doi: 10.3390/diseases5020015. Review. PMID: 28933368
2. Castro A, Malheiro J, Tafulo S, Dias L, Martins LS, Fonseca I, Beirão I, Castro-Henriques A, Cabrita A.HLA. Role of de novo donor-specific anti-HLA antibodies in kidney graft failure: A case-control study. 2017 Nov;90(5):267-275. doi: 10.1111/tan.13111. Epub 2017 Aug 24. PMID: 28776960
3. Malheiro J, Tafulo S, Dias L, Martins S, Fonseca I, Beirão I, Castro-Henriques A, Cabrita A.Impact on mid-term kidney graft outcomes of pretransplant anti-HLA antibodies detected by solid-phase assays: Do donor-specific antibodies tell the whole story? Hum Immunol. 2017 Sep;78(9):526-533. doi: 10.1016/j.humimm.2017.07.011. Epub 2017 Jul 19. PMID: 28732720
4. Santos J, Fonseca I, Malheiro J, Beirao I, Lobato L, Oliveira P, Cabrita A. End-stage renal disease versus death in a Portuguese cohort of elderly patients: an approach using competing event analysis. J Investig Med. 2017 Oct;65(7):1041-1048. doi: 10.1136/jim-2017-000480. Epub 2017 Jul 19. PMID: 28729248
5. Rocha A, Silva A, Cardoso M, Beirão I, Alves C, Teles P, Coelho T, Lobato L. Transthyretin (ATTR) amyloidosis nephropathy: lessons from a TTR stabilizer molecule. Amyloid. 2017 Mar;24(sup1):81-82. doi: 10.1080/13506129.2016.1277697. No abstract available. PMID:28434370

Ongoing projects:

• Portuguese Society of Nephrology, 054-17 (048-DEFI/048-CES) Observational Study. RICERCARE - Fabry disease screening program in non-dialysized patients with chronic renal disease, stadies 1 to 5. PI: Idalina Beirão, PhD and Fernando Teixeira e Costa, MD.
• Astellas Pharma Europe B.V., Protocol ISN 1517CL0610. "Study Phase III to evaluate the efficacy and the safety of FG4592 for the treatment of anemia in chronic kidney disease not receiving dialysis. PI: Idalina Beirão (Multicentric Clinical Trial)
• Bayer HealthCare,Protocol BAY 94-8862. Efficacy and safety of finerenone in subjects with type 2 diabetes mellitus and the clinical diagnosis of diabetic kidney disease - FIDELIO-DKD. PI: Idalina Beirão, PHD (Multicentric Clinical Trial)
• NORTE 2020 – Norte Regional Operational Program, Grant: Norte-01-0145-FEDER-000024. “Nephrocardio Risk – reliable biomarkers of chronic kidney disease and the associated cardiovascular risk. Construction of (bio)sensors od the selected biomarkers - projeto DESignBIOtecHealth-new technologies for three health challenges of modern societies: diabetes, drug abuse and kigney diseases. “ Research Team: UCIBIO/FFUP: Alice Santos Silva (Principal Investigator), Idalina Beirão, PHD (Investigator at Centro Hospitalar do Porto)

Prizes, honors, awards:

2016- 53TH ERA-EDTA CONGRESS: 8 ABSOLUTE BEST ABSTRACTS – “Impact of pre-transplant anti-MICA sensitization in graft rejection and survival”- Oral Communication (coauthor)

2015- Prémio “Ana Maria Correia” – Published manuscript “Analysis of preformed donor specific anti-HLA antibodies characteristics for prediction of antibody-mediated Rejection in kidney transplantation” (coauthor)

2014- Grant “ Best presentation”. "Is decreased erythropoietin production mediated by cytotoxic aggragates?" XIVTH International Symposium on Amyloidosis", Indianapolis, Indiana, USA. 2014.(coauthor)

2011- Prize “Sollari Allegro” 2011 (1º Prize) - Published manuscript “Erythropoietin production by distal nephron in normal and familiar amyloidotic adult human kidneys” (first auhor)

1998- “Prize Gulbenkian for young investigators” - Published manuscript "Familial Amyloid Polyneuropathy Type I (Portuguese): Distribution and characterization of renal amyloid deposits" (coauthor)

PhD thesis supervision (concluded):

• Luciana Maria Vaz Moreira, MsC. Doutoramento em Ciências Biomédicas, ICBAS-UP. Dissecting the molecular mechanisms and influence of the amyloid fibrils in EPO production and anemia in Familial Amyloidotic Polineuropathy.2015.

• Joaquim Jorge dos Anjos Malheiro, MD. Doutoramento em Ciências Médicas, ICBAS-UP Clinical management of anti-HLA and non-HLA antibodies role for outcomes improvement in kidney transplantation. 2018
• Inês Ribeiro Paciência. Doutoramento em Ciências Biomédicas, ICBAS-UP. Endocrine Disruptors and Asthma Associated Chemicals in Indoor Environment: evaluation and impact on childhood. 2020
• Sónia Isabel Costa Magalhães. Doutoramento em Ciências Biomédicas, ICBAS-UP. Suporte Social nos Doentes Renais Crónicos em Diálise: Pensionistas de invalidez vs pensionistas de velhice. 2021

MSc thesis supervision (concluded):

• Luciana Maria Vaz Moreira, MD. Mestrado em Ciências Biomédicas, FMUP-UP. Eritropoietina: produção renal, anemia e cancro. Faculdade de Medicina do Porto. 2008.