La Salete Martins, MD, PhD

Integrated PhD Researcher

orcid.org/0000-0002-6110-2102

Academic degrees:

PhD

Medical Doctor

Positions:

• Associate Professor, ICBAS – University of Porto;

Research interests:

• Kidney Transplantation and histocompatibility
• Pancreas Transplantation, indications, complications and outcomes
• Diabetic Nephropathy and end-stage renal disease
• Type 1 diabetes and systemic involvement

Research area keywords:

Pancreas transplantation, Pancreas autoimmunity, Transplantation outcomes, Quality of life, Type 1 diabetes, Graft rejection

Selected publications:

1. Martins LS, Oliveira JC, Vizcaíno JR, Fonseca I, Gouveia C, Silva D, Henriques AC, Noronha IL, Rodrigues A. Advanced glycation end products evolution after pancreas-kidney transplantation: plasmatic and cutaneous assessments. Oxid Med Cell Longev 2016; 2016: 2189582-2189592.
2. Martins LS, Malheiro J, Pedroso S, Almeida M, Dias L, Henriques AC, Silva D, Davide J, Cabrita A, Noronha IL, Rodrigues A. Pancreas-Kidney Transplantation: Impact of dialysis modality on the outcome. Transpl Int 2015; 28:972-979.
3. Martins LS, Outerelo C, Malheiro J, Fonseca IM, Henriques AC, Dias LS, Rodrigues AS, Cabrita AM, Noronha IL.Health-Related Quality Of Life may improve after transplantation in Pancreas-Kidney recipients. Clin Transplant 2015; 29:242-245.
4. Martins LS, Henriques AC, Fonseca IM, Rodrigues AS, Oliverira JC, Dores JM, Dias LS, Cabrita AM, Silva JD, Noronha IL. Pancreatic autoantibodies after pancreas-kidney transplantation - do they matter?. Clin Transplant. 2014; 28(4): 462-469.
5. Rocha A, Martins LS, Malheiro J, Dores J, Santos C, Henriques. Changes in bone mineral density following long-term simultaneous pancreaskidney transplantation. J Bone Miner Metab 2016;34:209-215.

Ongoing projects:

Portuguese Society of Transplantation, 2015: Characterization of donor-specific anti-HLA antibodies detected before kidney transplantation and their impact on kidney graft outcomes.  PI: Jorge Malheiro, MD. Co-Investigator: La Salete Martins 10%)

Concluded projects:

Comissão de Fomento do Ministério da Saúde, de Janeiro/1995: “Osteodistrofia Renal – evolução histológica após Transplante Renal”, concluído. PI: José Queirós. Co-investigator: La Salete Martins 50%)

Comissão de Fomento do Ministério da Saúde, Outubro/1997: “Diálise Peritoneal: estudo prospectivo de avaliação da função da membrana peritoneal”, concluído. PI: La Salete Martins.

Portuguese Society of Transplantation 2010 “Biochemical evolution of AGE in type 1 diabetics after receiving a kidney-pancreas transplant” – Concluded. PI: La Salete Martins

Portuguese Society of Transplantation 2011 “Histological evaluation with anti-AGE antibodies – evolution after kidney-pancreas transplantation in type 1 diabetic patients” – concluded. PI: La Salete Martins

Prizes, honors, awards:

Prémio Gulbenkian para Jovens Investigadores (Portugal, 2000) – pelo trabalho : “Neoplasias após Transplante Renal – 15 anos de experiência”. Primeira autora.

“2002 European Renal Association-European Dialysis and Transplantation Association Congress Grants for Young Investigators”, with the work “Lamivudine therapy for activated hepatitis B virus infection in renal transplant patients”. First author.

Prize Fresenius/ 2008 of the Portuguese Society of Nephrology, with the publication: “The influence of HLA mismatches and immunosuppression on kidney graft survival: an analysis of more than 1300 patients”. First author.

Prémio da Sociedade Portuguesa de Nefrologia, 2013, pela melhor apresentação na área de transplantação renal no seu Encontro Renal 2013, com o trabalho: “Resultados a longo-prazo no transplante de rim-pâncreas – análise de 150 doentes”. Primeira autora.

Prémio “Casuística” do XV Congresso Português de Endocrinologia, 2014, pelo trabalho “Transplante Reno-Pancreático no Centro Hospitalar do Porto”. Autores: R Almeida, L. Martins, J Dores, et al. Co-autora.

ESOT (European Society for Organ Transplantation) Young Investigation Award 2017, with the work: “Early antibody-mediated rejection C4d status remains a marker of prognosis in HLA-incompatible kidney transplantation”. PI: Jorge Malheiro. Co-investigator.

International collaborations:

• Irene Lourdes Noronha, Professora Titular, Universidade de São Paulo, Brasil. Pancreas and islet cell transplantation.

MSc thesis supervision (concluded):

• Nuno Moreira Fonseca, MIM – ICBAS-UP, Recurrence of focal segmental glomerulosclerosis after kidney transplantation, Julho 2012.
• Eduardo Pedro Varzim Miranda B Reis, MIM- ICBAS-UP, Transplante Renal no doente HIV, Julho 2013
• Ana Rita Fernandes Pinho Peixeiro, MIM – ICBAS-UP, Nefropatia por IgA: etiopatogenia e fatores de prognóstico, Julho 2014.
• Carolina Ruivo Mirada Gaspar, MIM – ICBAS-UP, Etiopatogenia da Diabetes tipo 1, Julho 2014.
• Ana Catarina Ribeiro Gomes, MIM – ICBAS-UP, Análise das indicações e critérios para o transplante pancreático nos doentes diabéticos tipo 2, Julho 2015.
• Sara Cristina Couto Pereira, MIM – ICBAS-UP, Diabetes Mellitus após Transplante Renal, Julho 2016.
• Rita Luís Miranda Silva, MIM – ICBAS-UP, Hipertensão no doente renal crónico: antes e depois do transplante renal, Julho 2017.

MSc thesis supervision (ongoing):

• Diogo Manuel Teixeira Mota, MIM – ICBAS-UP, Nefropatia do HIV, etiopatogenia e tratamento. Atualidades, Julho 2018.